Pharmacogenetic Testing

Pharmacogenetic testing is recommended by the U.S. FDA as well as the Department of Health and Human Services.

The Department of Health and Human services provides a list of FDA-approved drugs with Pharmacogenetic information in their labeling. Some biomarker information recommends specific actions to be taken by your physician. Pharmacogenetic testing information can provide your physician critical guidance in this area.

The goal of One Health Laboratory is to provide Pharmacogenetic testing to:

  • Optimize a clinician’s drug choice for a patient
  • Improve dosing for more effective therapy
  • Avoid serious Adverse Drug Reactions (ADR’s)
  • Decrease overall medical costs

Pharmacogenetic testing to assist the clinician in providing personalized health care is most prevalent in the following areas:

  • Cardiovascular Health
  • Psychiatry
  • Primary Care
  • Neurology
  • Woman’s Health
  • Pain Management

PHARMACOGENETIC BASICS

What do metabolizer phenotypes mean?
Knowing a patient’s genetic profile can help a
prescriber adjust patient drug therapy to improve therapeutic outcomes and reduce the risk ofadverse drug events (ADE).

Our Pharmacogenetic test report categorizes a patient into one of four metabolizer categories for each genetic pathway and interprets that data in the context of the following specialties: cardiology, pain management
and psychiatry.

ULTRA-RAPID METABOLIZERS

  • Increased risk of treatment failure from non-prodrugs* due to increased metabolism.
  • Increased risk of toxicity from prodrugs* due to excessive formation of active metabolites.

NORMAL METABOLIZERS

  • Normal drug metabolism should be expected.

INTERMEDIATE METABOLIZERS

  • Often a reduced dose of non-prodrugs* is suggested with close monitoring for ADE’s.
  • Administration of inhibitors could result in poor metabolizer ability; administration of inducers could improve metabolism.

POOR METABOLIZERS

  • Increased risk of toxicity from non-prodrugs* due to lack of metabolism.
  • Unlikely to benefit from prodrugs* due to reduced formation of active metabolites.

*Prodrugs undergo hepatic biotransformation in order to become active and exert the desired pharmacological effect.

ONE HEALTH’S TESTING COVERS THE WIDEST AREAS OF PATIENT TREATMENT AND ANALYZES THE GREATEST NUMBER OF GENES IN THE INDUSTRY

GENE NAME MAY APPLY TO SELECT MEDICATIONS WITHIN THESE CASES
CYP1A2 All therapeutic medication classes
CYP2C9 All therapeutic medication classes
CYP2C19 All therapeutic medication classes
CYP2D6 All therapeutic medication classes
CYP3A4 All therapeutic medication classes
CYP3A5 All therapeutic medication classes
SLC6A4 (SERT) Antidepressants
HTR2A SSRIs, Antipsychotics
COMT Antidepressant, Pain, ADHA
DRD2 Antipsychotics
MTHFR Adjunctive treatment for depression, Psychosis
VKORC1 Anticoagulation (warfarin)
OPRM1 Opioids
SLCO1B1 Statins (simvastatin)
ABCB1 Pain
ADRA2A Antidepressants, Antipsychotics, ADHD
F2 (Factor 2) Anticoagulants
FV (Factor V) Anticoagulants
HTR2C Antipsychotics
GRIK4 Glutamate functions of central nervous systems
NAT2 Arylamine, Hydrazine Drugs, Carcinogens
Apoε Hyperlipidemia

BENEFITS OF
PHARMACOGENETIC TESTING

Pharmacogenetic testing looks at how your unique genetic makeup can affect your response to medications and helps your clinician find the medications that may be right for you.

Through the analysis of certain genes that metabolize certain medicines, health care professionals can now have key information to determine the most appropriate dose to the most appropriate medicines for each individual patient.

The results of a Pharmacogenetic test allow a healthcare professional to make a more informed therapeutic decision. They may change the current medication or class of medication prescribed, adjust dosing based on the metabolic status or find more appropriate alternative medications based on the test results.

Pharmacogenetic testing allows your physician to understand how your genetic make-up determines how well a medicine works in your body, as well as what side effects will occur. Rather than having to take the standard trial-and-error approach to their patients’ prescription drug therapy, physicians can now prescribe the right medicine, for the right patient at the right time. Not only will this take the guesswork out of finding the right drug, it will reduce costs, speed recovery time and increase safety as the likelihood of adverse reactions is eliminated.